<!DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd"> <html xmlns="http://www.w3.org/1999/xhtml"> <head> <meta http-equiv="Content-Type" content="text/html; charset=ISO-8859-1" /> <title>Capsinoids</title> <style type="text/css"> <!-- body { margin-left: 0px; margin-top: 0px; margin-right: 0px; margin-bottom: 0px; background-color: #dadada; } --> </style> <script type="text/JavaScript"> <!-- function MM_preloadImages() { //v3.0 var d=document; if(d.images){ if(!d.MM_p) d.MM_p=new Array(); var i,j=d.MM_p.length,a=MM_preloadImages.arguments; for(i=0; i<a.length; i++) if (a[i].indexOf("#")!=0){ d.MM_p[j]=new Image; d.MM_p[j++].src=a[i];}} } function MM_swapImgRestore() { //v3.0 var i,x,a=document.MM_sr; for(i=0;a&&i<a.length&&(x=a[i])&&x.oSrc;i++) x.src=x.oSrc; } function MM_findObj(n, d) { //v4.01 var p,i,x; if(!d) d=document; if((p=n.indexOf("?"))>0&&parent.frames.length) { d=parent.frames[n.substring(p+1)].document; n=n.substring(0,p);} if(!(x=d[n])&&d.all) x=d.all[n]; for (i=0;!x&&i<d.forms.length;i++) x=d.forms[i][n]; for(i=0;!x&&d.layers&&i<d.layers.length;i++) x=MM_findObj(n,d.layers[i].document); if(!x && d.getElementById) x=d.getElementById(n); return x; } function MM_swapImage() { //v3.0 var i,j=0,x,a=MM_swapImage.arguments; document.MM_sr=new Array; for(i=0;i<(a.length-2);i+=3) if ((x=MM_findObj(a[i]))!=null){document.MM_sr[j++]=x; if(!x.oSrc) x.oSrc=x.src; x.src=a[i+2];} } //--> </script> <link href="researchCap.css" rel="stylesheet" type="text/css" /> <!-- GA script Start --> <script src="http://www.google-analytics.com/urchin.js" type="text/javascript"> </script> <script type="text/javascript"> _uacct = "UA-381460-10"; urchinTracker(); </script> <!-- GA script End --> </head> <body onload="MM_preloadImages('images/btn_over_back.jpg')"> <div align="center"> <table width="783" border="0" cellspacing="0" cellpadding="0"> <tr> <td valign="top"><img src="images/spacer.gif" width="1" height="32" /></td> </tr> <tr> <td valign="top">&nbsp;</td> </tr> <tr> <td valign="top"><table width="783" border="0" cellspacing="0" cellpadding="0"> <tr> <td width="1" rowspan="2" valign="top" bgcolor="#000000"><img src="images/spacer.gif" width="1" height="1" /></td> <td valign="top"><img src="images/header-h.jpg" alt="Capsinoids Research" width="774" height="106" /></td> <td width="1" rowspan="2" valign="top" bgcolor="#000000"><img src="images/spacer.gif" width="1" height="1" /></td> <td width="7" valign="top"><img src="images/headShad-h.gif" width="7" height="106" /></td> </tr> <tr> <td valign="top" bgcolor="#FFFFFF"><table width="774" border="0" cellspacing="0" cellpadding="0"> <tr> <td valign="top"><img src="images/spacer.gif" width="1" height="10" /></td> </tr> <tr> <td valign="top"><img src="images/spacer.gif" width="1" height="30" /></td> </tr> <tr> <td valign="top" class="addArticle"> <div class="addArticleTxt"> <p align="justify"> The following is a list of scientific articles on dihydrocapsiate, capsinoids and CH-19 Sweet, with links to article's full text.0The list consists of <span class="addArticleRedTxt">"Safety Studies"</span> and <span class="addArticleblueTxt">"Efficacy Studies"</span>. </p> <br /> </td> </tr> <tr> <td valign="top" class="addArticle" > <table cellpadding="0" cellspacing="0" class="safety"> <tr><td align=left>Safety Studies</td></tr> </table> <br /><br /><br /> </td> </tr> <tr> <td valign="top" class="addArticle" > <table cellpadding=0 cellspacing=0 class="keyreferences"> <tr><td align=left>Dihydrocapsiate</td></tr> </table> <br /> <br /><br /> </td> </tr> <tr> <td valign="top" class="addArticle" > <p align="justify">Kodama, T., T. Masuyama, T. Kayahara, S. Tsubuku, T. Ohishi, B.K. Bernard. <br /> "Studies of the Toxicological Potential of Capsinoids: XIV. A 26-Week Gavage Toxicity Study of Dihydrocapsiate in Rats" <br /><br /> Int. J. Toxicol. 29 (Suppl. 1) (2010): 27-54.<br /> </p> <p align="justify">Bernard, B.K., E. Watanabe, T. Kodama, S. Tsubuku, A. Otabe, M. Nakajima, S. Masumori, S. Shimada, J. Tanaka, T. Masuyama.<br /> "Studies of the Toxicological Potential of Capsinoids: V. Genotoxicity Studies of Dihydrocapsiate" <br /><br /> Int. J. Toxicol. 27 (Suppl. 3) (2008): 59-72.<br /> </p> <p align="justify">Bernard, B.K., E. Watanabe, T. Kodama, S. Tsubuku, A. Otabe, M. Ikeya, T. Matsuoka, T. Masuyama.<br /> "Studies of the Toxicological Potential of Capsinoids: IX. Teratology Studies of Dihydrocapsiate in Rats and Rabbits" <br /><br /> Int. J. Toxicol. 27 (Suppl. 3) (2008): 119-136.<br /> </p> <p align="justify">Bernard, B.K., K. Ubukata, R. Mihara, Y. Sato, H. Nemoto.<br /> "Studies of the Toxicological Potential of Capsinoids: XI. Pharmacokinetic and Tissue Distribution Study of <sup class="superscript">14</sup>C-Dihydrocapsiate (a Capsinoid) and Metabolites in Rats" <br /><br /> Int. J. Toxicol. 29 (Suppl. 1) (2010): 3-14.<br /> </p> <p align="justify">Kodama, T., E. Watanabe, S. Tsubuku, A. Otabe, M. Mochizuki, T. Masuyama, B.K. Bernard.<br /> "Studies of the Toxicological Potential of Capsinoids: VIII. A 13-Week Toxicity Study of Commercial-Grade Dihydrocapsiate in Rats" <br /><br /> Int. J. Toxicol. 27 (Suppl. 3) (2008): 101-118.<br /> </p> <p align="justify">Watanabe, E., T. Kodama, T. Masuyama, S. Tsubuku, A. Otabe, T. Ohishi, B.K. Bernard.<br /> "Studies of the Toxicological Potential of Capsinoids: VII. A 13-Week Toxicity Study of Dihydrocapsiate in Rats"<br /><br/> Int. J. Toxicol. 27 (Suppl. 3) (2008): 79-100.<br /> </p> <p align="justify">Watanabe, E., T. Kodama, T. Masuyama, S. Tsubuku, M. Nakajima, B.K. Bernard.<br /> "Studies of the Toxicological Potential of Capsinoids: VI. Single-Dose Toxicity Study and Micronucleus Test of Commercial-Grade Dihydrocapsiate"<br /><br /> Int. J. Toxicol. 27 (Suppl. 3) (2008): 73-78.<br /> </p> <br /> </td> </tr> <tr> <td valign="top" class="addArticle" > <table cellpadding=0 cellspacing=0 class="supreferences"> <tr><td align=left>Capsinoids and CH-19 Sweet extract</td></tr> </table> <br /><br /><br /> </td> </tr> <tr><td valign="top" class="addArticle" > <p align="justify">Bernard, B.K., E. Watanabe, T. Kodama, S. Tsubuku, A. Otabe, Y. Katsumata, T. Matsuoka, T. Masuyama.<br /> "Studies of the Toxicological Potential of Capsinoids: IV. Teratology Studies of CH-19 Sweet Extract in Rats and Rabbits"<br /><br /> Int. J. Toxicol. 27 (Suppl. 3) (2008): 41-58.<br /> </p> <p align="justify">Bernard, B.K., S. Tsubuku, T. Kayahara, K. Maeda, M. Hamada, T. Nakamura, Y. Shirai, A. Nakayama, S. Ueno,R. Mihara.<br /> "Studies of the Toxicological Potential of Capsinoids: X Safety Assessment and Pharmacokinetics of Capsinoids in Healthy Male Volunteers after a Single Oral Ingestion of CH-19 Sweet Extract"<br /><br /> Int. J. Toxicol. 27 (Suppl. 3) (2008): 137-147.<br /> </p> <p align="justify">Kodama, T., E. Watanabe, T. Masuyama, S. Tsubuku, A. Otabe, M. Mochizuki, B.K. Bernard.<br /> "Studies of the Toxicological Potential of Capsinoids: II. A 26-Week Daily Gavage Dosing Toxicity Study of CH-19 Sweet Extract in Rats"<br /><br /> Int. J. Toxicol. 27 (Suppl. 3) (2008): 11-28.<br /> </p> <p align="justify">Kodama, T., E. Watanabe, T. Masuyama, S. Tsubuku, A. Otabe, Y. Katsumata, B.K. Bernard.<br /> "Studies of the Toxicological Potential of Capsinoids: III. A Two-Generation Reproduction Study of CH-19 Sweet Extract in Rats"<br /><br /> Int. J. Toxicol. 27 (Suppl. 3) (2008): 29-40.<br /> </p> <p align="justify">Shirai, Y., S. Ueno, A. Nakayama, K. Ikeuchi, K. Ubukata, R. Mihara, B.K. Bernard. <br /> "Studies of the Toxicological Potential of Capsinoids: XII. A Pharmacokinetic Study of Capsinoid-Containing CH 19 Sweet Extract in Rats " <br /><br /> Int. J. Toxicol. 29 (Suppl. 1) (2010): 15-21.<br /> </p> <p align="justify">Takanohashi, T., M. Isaka, K. Ubukata, R. Mihara, B.K. Bernard. <br /> "Studies of the Toxicological Potential of Capsinoids: XIII. Inhibitory Effects of Capsaicin and Capsinoids on Cytochrome P450 3A4 in Human Liver Microsomes"<br /><br /> Int. J. Toxicol. 29 (Suppl. 1) (2010): 22-26.<br /> </p> <p align="justify">Watanabe, E., T. Kodama, T. Masuyama, S. Tsubuku, A. Otabe, M. Mochizuki, M. Nakajima, S. Masumori, B.K. Bernard.<br /> "Studies of the Toxicological Potential of Capsinoids: I. Single-Dose Toxicity Study and Genotoxicity Studies of CH-19 Sweet Extract"<br /><br /> Int. J. Toxicol. 27 (Suppl. 3) (2008): 1-10.<br /> </p> <p>&nbsp;</p> </tr> <tr><td valign="top" class="addArticle" > <table cellpadding=0 cellspacing=0 align=left class="other"> <tr><td>Efficacy Studies</td></tr> </table> <br /><br /> </td> </tr> <tr> <td valign="top"><img src="images/spacer.gif" width="1" height="30" /></td> </tr> <tr> <td valign="top"><table width="774" border="0" cellspacing="0" cellpadding="0"> <tr> <td width="277" valign="top"><table width="277" border="0" cellspacing="0" cellpadding="0"> <tr> <td valign="top" style="width: 277px"><div align="center"><img src="images/caption-h.gif" width="236" height="149" /></div></td> </tr> <tr> <td valign="top" style="width: 277px"><div align="center"><img src="images/pict1-h.jpg" width="236" height="186" /></div></td> </tr> <tr> <td valign="top" class="photocaption" style="width: 277px"><table width="267" border="0" cellspacing="0" cellpadding="0"> <tr> <td width="15" valign="top"><img src="images/spacer.gif" width="20" height="1" /></td> <td valign="top"><div align="left">CH-19 Sweet </div></td> </tr> </table></td> </tr> </table></td> <td rowspan="2" valign="top" class="mainTxt"><div align="left"> The following is a list of relevant scientific articles on capsinoids and CH-19 Sweet, with links either to each article's abstract or full text. </div> <p align="justify"> Miyako Yamasaki, Satoru Ebihara, Takae Ebihara, Shannon Freeman, Shinsuke Yamanda, Masanori Asada, Motoki Yoshida and Hiroyuki Arai, "Cough reflex and oral chemesthesis induced by capsaicin and capsiate in healthy never-smokers" Cough, 3 (2007): 9 <br> <a href="http://www.coughjournal.com/content/3/1/9" target="_blank" class="mainTxtBld">View Article &gt;</a></p> <p align="justify"> Sachiko Hachiya, Fuminori Kawabata, Koichiro Ohnuki, Naohiko Inoue, Hirotsugu Yoneda, Susumu Yazawa and Tohru Fushiki. "Effects of CH-19 Sweet, a Non-Pungent Cultivar of Red Pepper, on Sympathetic Nervous Activity, Body Temperature, Heart Rate, and Blood Pressure in Humans." Biosci. Biotechnol. Biochem. 71 (2007): 671-676. <br> <a href="http://www.jstage.jst.go.jp/article/bbb/71/3/671/_pdf" target="_blank" class="mainTxtBld">View Article &gt;</a></p> <p align="justify">Naohiko Inoue, Yoshiko Matsunaga, Hitoshi Satoh, and Michio Takahashi. "Enhanced Energy Expenditure and Fat Oxidation in Humans with High BMI Scores by the Ingestion of Novel and Non-Pungent Capsaicin Analogues (Capsinoids)." Biosci. Biotechnol. Biochem. 71 (2007): 380-389.<br /> <a href="http://www.capsinoidsresearch.com/pdf/jstage_jst_go.pdf" target="_blank" class="mainTxtBld">View Article &gt; </a></p> <p align="justify">Satoshi Haramizu, Wataru Mizunoya, Yoriko Masuda, Koichiro Ohnuki, Tatsuo Watanabe, Susumu Yazawa, and Tohru Fushiki. "Capsiate, a Nonpungent Capsaicin Analog, Increases Endurance Swimming Capacity of Mice by Stimulation of Vanilloid Receptors." Biosci. Biotechnol. Biochem. 70 (2006): 774-781.<br /> <a href="http://www.jstage.jst.go.jp/article/bbb/70/4/774/_pdf" target="_blank" class="mainTxtBld">View Article &gt; </a></p> <p align="justify"> Fuminori Kawabata, Naohiko Inoue, Susumu Yazawa, Teruo Kawada, Kazuo Inoue, and Tohru Fushiki. "Effects of CH-19 Sweet, a Non-Pungent Cultivar of Red Pepper, in Decreasing the Body Weight and Suppressing Body Fat Accumulation by Sympathetic Nerve Activation in Humans." Biosci. Biotechnol. Biochem. 70 (2006): 2824-2835.<br /> <a href="http://www.jstage.jst.go.jp/article/bbb/70/12/2824/_pdf" target="_blank" class="mainTxtBld">View Article &gt; </a></p> <p align="justify">Antonella Rosa, Monica Deiana, Giulia Corona, Angela Atzeri, Alessandra Incani, Giovanni Appendino and M. Assunta Dess. "Protective Effect of Capsinoid on Lipid Peroxidation in Rat Tissues Induced by Fe-NTA." Free Radic. Res. 39 (2005): 1155-1162.<br /> <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=16298741&dopt=Citation" target="_blank" class="mainTxtBld">View Article &gt; </a></p> <p align="justify">Yumiko Tani, Toshiaki Fujioka, Miyuki Sumioka, Yukio Furuichi, Hiroki Hamada and Tatsuo Watanabe. "Effects of Capsinoid on Serum and Liver Lipids in Hyperlipidemic Rats." J. Nutr. Sci. Vitaminol. 50 (2004): 351-355.<br /> <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=15754496&dopt=Citation" target="_blank" class="mainTxtBld">View Article &gt; </a></p> <p align="justify">T. Iida, T. Moriyama, K. Kobata, A. Morita, N. Murayama, S. Hashizume, T. Fushiki, S. Yazawa, T. Watanabe, and M. Tominaga. "TRPV1 Activation and Induction of Nociceptive Response by a Non-Pungent Capsaicin-Like Compound, Capsiate." Neuropharmacology 44 (2003): 958-967.<br /> <a href="http://biologie.kappa.ro/Literature/PDF_Archives/PDF_archive_2003/neuropharmacology/44/958.pdf" target="_blank" class="mainTxtBld">View Article &gt;</a></p> <p align="justify">Antonio Macho, Concepcin Lucena, Rocio Sancho, Nives Daddario, Alberto Minassi, Eduardo Muoz, Giovanni Appendino. "Non-pungent Capsaicinoids from Sweet Pepper Synthesis and Evaluation of the Chemopreventive and Anticancer Potential." Eur. J. Nutr. 42 (2003): 2-9.<br/> <a href="http://cat.inist.fr/?aModele=afficheN&cpsidt=14541456" target="_blank" class="mainTxtBld">View Article &gt; </a> </p> <p align="justify">Antonio Macho, Rocio Sancho, Alberto Minassi, Giovanni Appendino, Alfons Lawen and Eduardo Munoz. "Involvement of Reactive Oxygen Species in Capsaicinoid-induced Apoptosis in Transformed Cells." Free Radic. Res. 37 (2003): 611-619.<br/> <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=12868488&dopt=Citation" target="_blank" class="mainTxtBld">View Article &gt; </a> </p> <p align="justify">Yoriko Masuda, Satoshi Haramizu, Kasumi Oki, Koichiro Ohnuki, Tatsuo Watanabe, Susumu Yazawa, Teruo Kawada, Shu-ichi Hashizume, and Tohru Fushiki. "Upregulation of Uncoupling Proteins by Oral Administration of Capsiate, a Nonpungent Capsaicin Analog." J. Appl. Physiol. 95 (2003): 2408-2415.<br/> <a href="http://jap.physiology.org/cgi/reprint/95/6/2408.pdf" target="_blank" class="mainTxtBld">View Article &gt; </a> </p> <p align="justify">Kenji Kobata, Manami Kawaguchi and Tatsuo Watanabe. "Enzymatic Synthesis of a Capsinoid by the Acylation of Vanillyl Alcohol with Fatty Acid Derivatives Catalyzed by Lipases." Biosci. Biotechnol. Biochem. 66 (2002): 319-327.<br/> <a href="http://www.jstage.jst.go.jp/article/bbb/66/2/319/_pdf" target="_blank" class="mainTxtBld">View Article &gt; </a> </p> <p align="justify">Antonella Rosa, Monica Deiana, Viviana Casu, Stefania Paccagnini, Giovanni Appendino, Mauro Ballero and M. Assunta Dessia. "Antioxidant Activity of Capsinoids." J. Agric. Food Chem. 50 (2002): 7396-7401.<br/> <a href="http://152.1.118.33/Files/Journal%20of%20Agricultural%20and%20Food%20Chemistry%202002%2050%20(25)%207396-7401.pdf" target="_blank" class="mainTxtBld">View Article &gt; </a> </p> <p align="justify">Roco Sancho, Concepcin Lucena, Antonio Macho, Marco A. Calzado, Magdalena Blanco-Molina, Alberto Minassi, Giovanni Appendino and Eduardo Muoz. "Immunosuppressive Activity of Capsaicinoids: Capsiate Derived from Sweet Peppers Inhibits NF-kappaB Activation and is a Potent Anti-inflammatory Compound in Vivo." Eur. J. Immunol. 32 (2002): 1753-1763.<br/> <a href="http://www3.interscience.wiley.com/cgi-bin/abstract/94515784/ABSTRACT" target="_blank" class="mainTxtBld">View Article &gt; </a> </p> <p align="justify">Koichiro Ohnuki, Satoshi Haramizu, Kasumi Oki, Tatsuo Watanabe, Susumu Yazawa, and Tohru Fushiki. "Administration of Capsiate, a Non-Pungent Capsaicin Analog, Promotes Energy Metabolism and Suppresses Body Fat Accumulation in Mice." Biosci. Biotechnol. Biochem. 65 (2001): 2735-2740.<br/> <a href="http://www.jstage.jst.go.jp/article/bbb/65/12/2735/_pdf" target="_blank" class="mainTxtBld">View Article &gt; </a> </p> <p align="justify">Koichiro Ohnuki, Satoshi Haramizu, Tatsuo Watanabe, Susumu Yazawa, and Tohru Fushiki. "CH-19 Sweet, Nonpungent Cultivar of Red Pepper, Increased Body Temperature in Mice with Vanilloid Receptors Stimulation by Capsiate." J. Nutr. Sci. Vitaminol. 47 (2001): 295-298. <br/> <a href="http://www.capsinoidsresearch.com/pdf/CH-19-Abstract.pdf" target="_blank" class="mainTxtBld">View Article &gt; </a> </p> <p align="justify">Koichiro Ohnuki, Shoji Niwa, Satoshi Maeda, Naohiko Inoue, Susumu Yazawa, and Tohru Fushiki. "CH-19 Sweet, a Non-Pungent Cultivar of Red Pepper, Increased Body Temperature and Oxygen Consumption in Humans." Biosci. Biotechnol. Biochem. 65 (2001): 2033-2036.<br/> <a href="http://www.jstage.jst.go.jp/article/bbb/65/9/2033/_pdf" target="_blank" class="mainTxtBld">View Article &gt; </a> </p> <p align="justify">Kenji Kobata, Kouzou Sutoh, Tomoko Todo, Susumu Yazawa, Kazuo Iwai and Tatsuo Watanabe. "Nordihydrocapsiate, a New Capsinoid from the Fruits of a Nonpungent Pepper, Capsicum annuum." J. Nat. Prod. 62 (1999): 335-336.<br/> <a href="http://www.geocities.com/NapaValley/3378/capsaicinarticle14.pdf" target="_blank" class="mainTxtBld">View Article &gt; </a> </p> <p align="justify">Kenji Kobata, Tomoko Todo, Susumu Yazawa, Kazuo Iwai, and Tatsuo Watanabe. "Novel Capsaicinoid-like Substances, Capsiate and Dihydrocapsiate, from the Fruits of a Nonpungent Cultivar, CH-19 Sweet, of Pepper (Capsicum annuum L.)." J. Agric. Food Chem. 46 (1998): 1695-1697.<br/> <a href="http://pubs.acs.org/cgi-bin/abstract.cgi/jafcau/1998/46/i05/abs/jf980135c.html" target="_blank" class="mainTxtBld">View Article &gt; </a> </p> </td> <td valign="top"><img src="images/spacer.gif" width="30" height="1" /></td> </tr> <tr> <td valign="bottom"><div align="center"> <table width="236" border="0" cellspacing="0" cellpadding="0"> <tr> <td><img src="images/ajinimotoLogo-h.gif" width="236" height="41" /></td> </tr> <tr> <td><div align="center" class="footer">Copyright 2007, Ajinomoto Co., Inc. </div></td> </tr> <tr> <td><img src="images/spacer.gif" width="1" height="12" /></td> </tr> </table> </div></td> <td valign="top">&nbsp;</td> </tr> <tr> <td valign="bottom"><img src="images/spacer.gif" width="1" height="20"/></td> <td valign="top" class="mainTxt">&nbsp;</td> <td valign="top">&nbsp;</td> </tr> </table></td> </tr> </table></td> <td valign="top" background="images/shadSide-h.gif">&nbsp;</td> </tr> </table></td> </tr> <tr> <td valign="top"><img src="images/footShad-h.gif" width="783" height="9" /></td> </tr> </table> </div> </body> </html>