Capsinoids Research

The following is a list of scientific articles on dihydrocapsiate, capsinoids and CH-19 Sweet, with links to article's full text. The list consists of "Safety Studies" and "Efficacy Studies".


Safety Studies



Dihydrocapsiate



Kodama, T., T. Masuyama, T. Kayahara, S. Tsubuku, T. Ohishi, B.K. Bernard.
"Studies of the Toxicological Potential of Capsinoids: XIV. A 26-Week Gavage Toxicity Study of Dihydrocapsiate in Rats"

Int. J. Toxicol. 29 (Suppl. 1) (2010): 27-54.

Bernard, B.K., E. Watanabe, T. Kodama, S. Tsubuku, A. Otabe, M. Nakajima, S. Masumori, S. Shimada, J. Tanaka, T. Masuyama.
"Studies of the Toxicological Potential of Capsinoids: V. Genotoxicity Studies of Dihydrocapsiate"

Int. J. Toxicol. 27 (Suppl. 3) (2008): 59-72.

Bernard, B.K., E. Watanabe, T. Kodama, S. Tsubuku, A. Otabe, M. Ikeya, T. Matsuoka, T. Masuyama.
"Studies of the Toxicological Potential of Capsinoids: IX. Teratology Studies of Dihydrocapsiate in Rats and Rabbits"

Int. J. Toxicol. 27 (Suppl. 3) (2008): 119-136.

Bernard, B.K., K. Ubukata, R. Mihara, Y. Sato, H. Nemoto.
"Studies of the Toxicological Potential of Capsinoids: XI. Pharmacokinetic and Tissue Distribution Study of 14C-Dihydrocapsiate (a Capsinoid) and Metabolites in Rats"

Int. J. Toxicol. 29 (Suppl. 1) (2010): 3-14.

Kodama, T., E. Watanabe, S. Tsubuku, A. Otabe, M. Mochizuki, T. Masuyama, B.K. Bernard.
"Studies of the Toxicological Potential of Capsinoids: VIII. A 13-Week Toxicity Study of Commercial-Grade Dihydrocapsiate in Rats"

Int. J. Toxicol. 27 (Suppl. 3) (2008): 101-118.

Watanabe, E., T. Kodama, T. Masuyama, S. Tsubuku, A. Otabe, T. Ohishi, B.K. Bernard.
"Studies of the Toxicological Potential of Capsinoids: VII. A 13-Week Toxicity Study of Dihydrocapsiate in Rats"

Int. J. Toxicol. 27 (Suppl. 3) (2008): 79-100.

Watanabe, E., T. Kodama, T. Masuyama, S. Tsubuku, M. Nakajima, B.K. Bernard.
"Studies of the Toxicological Potential of Capsinoids: VI. Single-Dose Toxicity Study and Micronucleus Test of Commercial-Grade Dihydrocapsiate"

Int. J. Toxicol. 27 (Suppl. 3) (2008): 73-78.


Capsinoids and CH-19 Sweet extract



Bernard, B.K., E. Watanabe, T. Kodama, S. Tsubuku, A. Otabe, Y. Katsumata, T. Matsuoka, T. Masuyama.
"Studies of the Toxicological Potential of Capsinoids: IV. Teratology Studies of CH-19 Sweet Extract in Rats and Rabbits"

Int. J. Toxicol. 27 (Suppl. 3) (2008): 41-58.

Bernard, B.K., S. Tsubuku, T. Kayahara, K. Maeda, M. Hamada, T. Nakamura, Y. Shirai, A. Nakayama, S. Ueno,R. Mihara.
"Studies of the Toxicological Potential of Capsinoids: X Safety Assessment and Pharmacokinetics of Capsinoids in Healthy Male Volunteers after a Single Oral Ingestion of CH-19 Sweet Extract"

Int. J. Toxicol. 27 (Suppl. 3) (2008): 137-147.

Kodama, T., E. Watanabe, T. Masuyama, S. Tsubuku, A. Otabe, M. Mochizuki, B.K. Bernard.
"Studies of the Toxicological Potential of Capsinoids: II. A 26-Week Daily Gavage Dosing Toxicity Study of CH-19 Sweet Extract in Rats"

Int. J. Toxicol. 27 (Suppl. 3) (2008): 11-28.

Kodama, T., E. Watanabe, T. Masuyama, S. Tsubuku, A. Otabe, Y. Katsumata, B.K. Bernard.
"Studies of the Toxicological Potential of Capsinoids: III. A Two-Generation Reproduction Study of CH-19 Sweet Extract in Rats"

Int. J. Toxicol. 27 (Suppl. 3) (2008): 29-40.

Shirai, Y., S. Ueno, A. Nakayama, K. Ikeuchi, K. Ubukata, R. Mihara, B.K. Bernard.
"Studies of the Toxicological Potential of Capsinoids: XII. A Pharmacokinetic Study of Capsinoid-Containing CH 19 Sweet Extract in Rats "

Int. J. Toxicol. 29 (Suppl. 1) (2010): 15-21.

Takanohashi, T., M. Isaka, K. Ubukata, R. Mihara, B.K. Bernard.
"Studies of the Toxicological Potential of Capsinoids: XIII. Inhibitory Effects of Capsaicin and Capsinoids on Cytochrome P450 3A4 in Human Liver Microsomes"

Int. J. Toxicol. 29 (Suppl. 1) (2010): 22-26.

Watanabe, E., T. Kodama, T. Masuyama, S. Tsubuku, A. Otabe, M. Mochizuki, M. Nakajima, S. Masumori, B.K. Bernard.
"Studies of the Toxicological Potential of Capsinoids: I. Single-Dose Toxicity Study and Genotoxicity Studies of CH-19 Sweet Extract"

Int. J. Toxicol. 27 (Suppl. 3) (2008): 1-10.

 

Efficacy Studies


CH-19 Sweet
The following is a list of relevant scientific articles on capsinoids and CH-19 Sweet, with links either to each article's abstract or full text.

Miyako Yamasaki, Satoru Ebihara, Takae Ebihara, Shannon Freeman, Shinsuke Yamanda, Masanori Asada, Motoki Yoshida and Hiroyuki Arai, "Cough reflex and oral chemesthesis induced by capsaicin and capsiate in healthy never-smokers" Cough, 3 (2007): 9
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Sachiko Hachiya, Fuminori Kawabata, Koichiro Ohnuki, Naohiko Inoue, Hirotsugu Yoneda, Susumu Yazawa and Tohru Fushiki. "Effects of CH-19 Sweet, a Non-Pungent Cultivar of Red Pepper, on Sympathetic Nervous Activity, Body Temperature, Heart Rate, and Blood Pressure in Humans." Biosci. Biotechnol. Biochem. 71 (2007): 671-676.
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Naohiko Inoue, Yoshiko Matsunaga, Hitoshi Satoh, and Michio Takahashi. "Enhanced Energy Expenditure and Fat Oxidation in Humans with High BMI Scores by the Ingestion of Novel and Non-Pungent Capsaicin Analogues (Capsinoids)." Biosci. Biotechnol. Biochem. 71 (2007): 380-389.
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Satoshi Haramizu, Wataru Mizunoya, Yoriko Masuda, Koichiro Ohnuki, Tatsuo Watanabe, Susumu Yazawa, and Tohru Fushiki. "Capsiate, a Nonpungent Capsaicin Analog, Increases Endurance Swimming Capacity of Mice by Stimulation of Vanilloid Receptors." Biosci. Biotechnol. Biochem. 70 (2006): 774-781.
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Fuminori Kawabata, Naohiko Inoue, Susumu Yazawa, Teruo Kawada, Kazuo Inoue, and Tohru Fushiki. "Effects of CH-19 Sweet, a Non-Pungent Cultivar of Red Pepper, in Decreasing the Body Weight and Suppressing Body Fat Accumulation by Sympathetic Nerve Activation in Humans." Biosci. Biotechnol. Biochem. 70 (2006): 2824-2835.
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Antonella Rosa, Monica Deiana, Giulia Corona, Angela Atzeri, Alessandra Incani, Giovanni Appendino and M. Assunta DessÌ. "Protective Effect of Capsinoid on Lipid Peroxidation in Rat Tissues Induced by Fe-NTA." Free Radic. Res. 39 (2005): 1155-1162.
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Yumiko Tani, Toshiaki Fujioka, Miyuki Sumioka, Yukio Furuichi, Hiroki Hamada and Tatsuo Watanabe. "Effects of Capsinoid on Serum and Liver Lipids in Hyperlipidemic Rats." J. Nutr. Sci. Vitaminol. 50 (2004): 351-355.
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T. Iida, T. Moriyama, K. Kobata, A. Morita, N. Murayama, S. Hashizume, T. Fushiki, S. Yazawa, T. Watanabe, and M. Tominaga. "TRPV1 Activation and Induction of Nociceptive Response by a Non-Pungent Capsaicin-Like Compound, Capsiate." Neuropharmacology 44 (2003): 958-967.
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Antonio Macho, Concepción Lucena, Rocio Sancho, Nives Daddario, Alberto Minassi, Eduardo Muñoz, Giovanni Appendino. "Non-pungent Capsaicinoids from Sweet Pepper Synthesis and Evaluation of the Chemopreventive and Anticancer Potential." Eur. J. Nutr. 42 (2003): 2-9.
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Antonio Macho, Rocio Sancho, Alberto Minassi, Giovanni Appendino, Alfons Lawen and Eduardo Munoz. "Involvement of Reactive Oxygen Species in Capsaicinoid-induced Apoptosis in Transformed Cells." Free Radic. Res. 37 (2003): 611-619.
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Yoriko Masuda, Satoshi Haramizu, Kasumi Oki, Koichiro Ohnuki, Tatsuo Watanabe, Susumu Yazawa, Teruo Kawada, Shu-ichi Hashizume, and Tohru Fushiki. "Upregulation of Uncoupling Proteins by Oral Administration of Capsiate, a Nonpungent Capsaicin Analog." J. Appl. Physiol. 95 (2003): 2408-2415.
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Kenji Kobata, Manami Kawaguchi and Tatsuo Watanabe. "Enzymatic Synthesis of a Capsinoid by the Acylation of Vanillyl Alcohol with Fatty Acid Derivatives Catalyzed by Lipases." Biosci. Biotechnol. Biochem. 66 (2002): 319-327.
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Antonella Rosa, Monica Deiana, Viviana Casu, Stefania Paccagnini, Giovanni Appendino, Mauro Ballero and M. Assunta Dessia. "Antioxidant Activity of Capsinoids." J. Agric. Food Chem. 50 (2002): 7396-7401.
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Rocío Sancho, Concepción Lucena, Antonio Macho, Marco A. Calzado, Magdalena Blanco-Molina, Alberto Minassi, Giovanni Appendino and Eduardo Muñoz. "Immunosuppressive Activity of Capsaicinoids: Capsiate Derived from Sweet Peppers Inhibits NF-kappaB Activation and is a Potent Anti-inflammatory Compound in Vivo." Eur. J. Immunol. 32 (2002): 1753-1763.
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Koichiro Ohnuki, Satoshi Haramizu, Kasumi Oki, Tatsuo Watanabe, Susumu Yazawa, and Tohru Fushiki. "Administration of Capsiate, a Non-Pungent Capsaicin Analog, Promotes Energy Metabolism and Suppresses Body Fat Accumulation in Mice." Biosci. Biotechnol. Biochem. 65 (2001): 2735-2740.
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Koichiro Ohnuki, Satoshi Haramizu, Tatsuo Watanabe, Susumu Yazawa, and Tohru Fushiki. "CH-19 Sweet, Nonpungent Cultivar of Red Pepper, Increased Body Temperature in Mice with Vanilloid Receptors Stimulation by Capsiate." J. Nutr. Sci. Vitaminol. 47 (2001): 295-298.
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Koichiro Ohnuki, Shoji Niwa, Satoshi Maeda, Naohiko Inoue, Susumu Yazawa, and Tohru Fushiki. "CH-19 Sweet, a Non-Pungent Cultivar of Red Pepper, Increased Body Temperature and Oxygen Consumption in Humans." Biosci. Biotechnol. Biochem. 65 (2001): 2033-2036.
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Kenji Kobata, Kouzou Sutoh, Tomoko Todo, Susumu Yazawa, Kazuo Iwai and Tatsuo Watanabe. "Nordihydrocapsiate, a New Capsinoid from the Fruits of a Nonpungent Pepper, Capsicum annuum." J. Nat. Prod. 62 (1999): 335-336.
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Kenji Kobata, Tomoko Todo, Susumu Yazawa, Kazuo Iwai, and Tatsuo Watanabe. "Novel Capsaicinoid-like Substances, Capsiate and Dihydrocapsiate, from the Fruits of a Nonpungent Cultivar, CH-19 Sweet, of Pepper (Capsicum annuum L.)." J. Agric. Food Chem. 46 (1998): 1695-1697.
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